研究業績ACHIEVEMENT

原著論文

  1. Nakahashi-Oda C, Fujiyama S, Nakazawa Y, Kanemaru K, Wang Y, Lyu W, Shichita T, Kitaura J, Abe F, Shibuya A. CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke. Sci Immunol. 6(64):eabe7915 (2021)
  2. Nakamura K, Sakai S, Tsuyama J, Nakamura A, Otani K, Kurabayashi K, Yogiashi Y, Masai H, Shichita T. Extracellular DJ-1 induces sterile inflammation in the ischemic brain. PLOS Biol. 19(5):e3000939 (2021)
  3. Ito M, Komai K, Omata-Mise S, Iizuka-Koga M, Noguchi Y, Kondo T, Sakai R, Matsuo K, Nakayama T, Yoshi O, Nakatsukasa H, Chikuma S, Shichita T, Yoshimura A. Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery. Nature. 565(7738):246-250 (2019)
  4. Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, Koshida R, Takahashi S, Kodama T, Yoshimura A. Mafb prevents excess inflammation after ischemic stroke by accelerating clearance of danger signals through MSR1. Nat Med. 23(6):723-732 (2017)
  5. Kondo T, Morita R, Okuzono Y, Nakatsukasa H, Sekiya T, Chikuma S, Shichita T, Kanamori M, Kubo M, Koga K, Miyazaki T, Kassai Y, Yoshimura A. Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy. Nat Commun. 8:15338 (2017)
  6. Komai K, Shichita T, Ito M, Kanamori M, Chikuma S, Yoshimura A. Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation. Int Immunol. 29(2):59-70 (2017)
  7. Sakaguchi R, Chikuma S, Shichita T, Morita R, Sekiya T, Ouyang W, Ueda T, Seki H, Morisaki H, Yoshimura A. Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22. Int Immunol. 28(5):233-243 (2016)
  8. Sekiya T, Kondo T, Shichita T, Morita R, Ichinose H, Yoshimura A. Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells. J Exp Med. 212(10):1623-1640 (2015)
  9. Suzuki M, Morita R, Hirata Y, Shichita T, Yoshimura A. Spred1, a Suppressor of the Ras-ERK Pathway, Negatively Regulates Expansion and Function of Group 2 Innate Lymphoid Cells. J Immunol. 195(3):1273-1281 (2015)
  10. Kashiwagi I, Morita R, Shichita T, Komai K, Saeki K, Matsumoto M, Takeda K, Nomura M, Hayashi A, Kanai T, Yoshimura A. Smad2 and Smad3 Inversely Regulate TGF-β Autoinduction in Clostridium butyricum-Activated Dendritic Cells. Immunity. 43(1):65-79 (2015)
  11. Ito M, Shichita T, Okada M, Komine R, Noguchi Y, Yoshimura A, and Morita R. Bruton's tyrosine kinase (BTK) is an essential component for NLRP3 inflammasome activation and a potential therapeutic target for inflammation after ischemic brain injury. Nat Commun. 6: 7360 (2015)
  12. Morita R, Suzuki M, Kasahara H, Shimizu N, Shichita T, Sekiya T, Kimura A, Sasaki K, Yasukawa H, Yoshimura A. ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells. Proc Natl Acad Sci U S A. 112(1): 160-165 (2015)
  13. Takasato F, Morita R, Shichita T, Sekiya T, Morikawa Y, Kuroda T, Niimi M, Yoshimura A.　Prevention of allogeneic cardiac graft rejection by transfer of ex vivo expanded antigen-specific regulatory T-cells. PLoS One. 9(2): e87722 (2014)
  14. Abe H, Kimura A, Tsuruta S, Fukaya T, Sakaguchi R, Morita R, Sekiya T, Shichita T, Chayama K, Fujii-Kuriyama Y, Yoshimura A. Aryl hydrocarbon receptor plays protective roles in ConA-induced hepatic injury by both suppressing IFN-γ expression and inducing IL-22. Int Immunol. 26(3): 129-137 (2013)
  15. Nishimoto S, Kotani H, Tsuruta S, Shimizu N, Ito M, Shichita T, Morita R, Takahashi H, Amagai M, Yoshimura A. Th17 cells carrying TCR recognizing epidermal autoantigen induce psoriasis-like skin inflammation. J Immunol. 191(6): 3065-3072 (2013)
  16. Tamiya T, Ichiyama K, Kotani H, Fukaya T, Sekiya T, Shichita T, Honma K, Yui K, Matsuyama T, Nakao T, Fukuyama S, Inoue H, Nomura M, Yoshimura A. Smad2/3 and IRF4 play a cooperative role in IL-9-producing T cell induction. J Immunol. 191(5): 2360-2371 (2013)
  17. Hasegawa E, Sonoda KH, Shichita T, Morita R, Sekiya T, Kimura A, Oshima Y, Takeda A, Yoshimura A. IL-23-independent induction of IL-17 from gdT cells and innate lymphoid cells promotes experimental intraocular neovascularization. J Immunol. 190(4):1778-1787 (2013)
  18. Yan X, Shichita T, Katsumata Y, Matsuhashi T, Ito H, Ito K, Anzai A, Endo J, Tamura Y, Kimura K, Fujita J, Shinmura K, Shen W, Yoshimura A, Fukuda K, Sano M. Deleterious effect of the IL-23/IL-17A axis and γδT cells on left ventricular remodeling after myocardial infarction. J Am Heart Assoc. 1(5): e004408 (2012)
  19. Yoshida R, Suzuki M, Sakaguchi R, Hasegawa E, Kimura A, Shichita T, Sekiya T, Shiraishi H, Shimoda K, Yoshimura A. Forced expression of stabilized c-Fos in dendritic cells reduces cytokine production and immune responses in vivo. Biochem Biophys Res Commun. 423(2): 247-252 (2012)
  20. Yoshida H, Kimura A, Fukaya T, Sekiya T, Morita R, Shichita T, Inoue H, Yoshimura A. Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation. Biochem Biophys Res Commun. 418(2): 234-40 (2012)
  21. Shichita T, Hasegawa E, Kimura A, Morita R, Sakaguchi R, Takada I, Sekiya T, Ooboshi H, Kitazono T, Yanagawa T, Ishii T, Takahashi H, Mori S, Nishibori M, Kuroda K, Miyake K, Akira S, Yoshimura A. Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med. 18(6): 911-917 (2012)
  22. Ichiyama K, Sekiya T, Inoue N, Tamiya T, Kashiwagi I, Kimura A, Morita R, Muto G, Shichita T, Takahashi R, Yoshimura A. Transcription factor Smad-independent T helper 17 cell induction by transforming-growth factor- β is mediated by suppression of Eomesodermin. Immunity. 34(5):741-754 (2011)
  23. Konoeda F, Shichita T, Yoshida H, Sugiyama Y, Muto G, Hasegawa E, Morita R, Suzuki N, Yoshimura A. Therapeutic effect of IL-12/23 and their signaling pathway blockade on brain ischemia model. Biochem Biophys Res Commun. 402(3): 500-506 (2010)
  24. Shichita T, Sugiyama Y, Ooboshi H, Sugimori H, Nakagawa R, Takada I, Iwaki T, Okada Y, Iida M, Cua DJ, Iwakura Y, Yoshimura A. Pivotal role of cerebral interleukin-17-producing gammadelta T cells in the delayed phase of ischemic brain injury. Nat Med. 15(8):946-50 (2009)
  25. Shichita T, Ogata T, Yasaka M, Yasumori K, Inoue T, Ibayashi S, Iida M, Okada Y. Angiographical characteristics of radiation-induced carotid arterial stenosis. Angiology. 60(3):276-282 (2009)
  26. Matsumura Y, Kobayashi T, Ichiyama K, Yoshida R, Hashimoto M, Takimoto T, Tanaka K, Chinen T, Shichita T, Wyss-Coray T, Sato K, Yoshimura A. Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3- deficient dendritic cells. J Immunol. 179:2170-2179 (2007)
  27. Mori H, Shichita T, Yu Q, Yoshida R, Hashimoto M, Okamoto F, Torisu T, Nakaya M, Kobayashi T, Takaesu G, Yoshimura A. Suppression of SOCS3 expression in the pancreatic β-cell leads to resistance to type 1 diabetes. Biochem Biophys Res Commun. 359:952-958 (2007)
  28. Ooboshi H, Ibayashi S, Shichita T, Kumai Y, Takada J, Ago T, Arakawa S, Sugimori H, Kamouchi M, Kitazono T, Iida M. Postischemic gene transfer of Interleukin-10 protect against both focal and global brain ischemia. Circulation. 111:913-919 (2005)

総説・著書

  1. Shichita T, Ooboshi H, Yoshimura A. Neuroimmune mechanisms mediating post-ischemic brain injury and repair. Nat Rev Neurosci. 24(5):299-312 (2023)
  2. Koyama R, Shichita T. Glial roles in sterile inflammation after ischemic stroke. Neurosci Res. (2022)
  3. Sakai S, Shichita T. Role of alarmins in poststroke inflammation and neuronal repair. Semin Immunopathol. 187:67-71 (2023)
  4. 七田　崇：脳血管障害と炎症細胞．最新臨床脳卒中学第2版下巻 日本臨牀増刊80(2):668-672 (2022)
  5. 中村朱里、七田　崇：脳梗塞における神経細胞死の誘導機構　医学のあゆみ　283(5):506-510 (2022)
  6. 中村幸太郎、七田　崇：脳梗塞後のDAMPsによる無菌的炎症の役割．実験医学増刊 39(15):2415-2420 (2021)
  7. Otani K, Shichita T. Cerebral sterile inflammation in neurodegenerative diseases. Inflamm Regen. 40(1):28 (2020)
  8. Nakamura A, Otani K, Shichita T. Lipid mediators and sterile inflammation in ischemic stroke. Int Immunol. 32(11):719-725 (2020)
  9. 中村朱里、七田　崇：脳梗塞における炎症と脂質メディエーター．臨床免疫・アレルギー科 74(5):1-6 (2020)
  10. 津山淳、七田　崇：脳虚血後の炎症と修復における自然免疫の役割．実験医学増刊 37(17):2861-2866 (2019)
  11. 七田　崇：ラボ百景．実験医学 37(13):2216-2217 (2019)
  12. 七田　崇：加齢と脳血管障害．アンチ・エイジング医学 15(3):37-41 (2019)
  13. Nakamura K, Shichita T. Cellular and molecular mechanisms of sterile inflammation in ischemic stroke. J Biochem. 165(6):459-464 (2019) doi: 10.1093/jb/mvz017
  14. 中村幸太郎、七田　崇：脳梗塞後における無菌的炎症のメカニズム．The Mt.Fuji Workshop on CVD Proceedings 37:25-29 (2019)
  15. Tsuyama J, Nakamura A, Ooboshi H, Yoshimura A, Shichita T. Pivotal role of innate myeloid cells in cerebral post-ischemic sterile inflammation. Semin Immunopathol. 40(6):523-538 (2018)
  16. Sakai S, Shichita T. Inflammation and neural repair after ischemic brain injury. Neurochem Int. pii: S0197-0186(18)30298-5 (2018)
  17. 七田　崇：脳梗塞における無菌的な炎症メカニズムの解明．神経化学 57(2):47-53 (2018)
  18. 七田　崇：脳梗塞における無菌的炎症とマクロファージ．細胞 51(1):20-23 (2018)
  19. 七田　崇：脳梗塞における自然免疫系のかかわり．医学のあゆみ 265(13):1292-1295 (2018)
  20. 中村幸太郎、中村朱里、大星博明、七田　崇：脳梗塞における炎症の役割．日本脳循環代謝学会雑誌 30(1):77-81 (2018)
  21. 七田　崇：脳卒中病態学のススメ「13.D. 神経細胞保護療法　免疫的アプローチ」251-256 (2018)
  22. 七田　崇：脳梗塞における炎症惹起・収束メカニズム．日本薬理学雑誌 151(1):9-14 (2018)
  23. 七田　崇、吉村昭彦：スカベンジャー受容体を介した無菌的炎症の収束メカニズム．生化学 90(1):99-102 (2018)
  24. 七田　崇、吉村昭彦：脳梗塞後の無菌的炎症とその収束のメカニズム．実験医学 35(14):2390-2393 (2017)
  25. 津山 淳、七田 崇：マクロファージによる脳虚血後炎症の制御．炎症と免疫 25(6):547-552 (2017)
  26. 伊藤美菜子、七田　崇、吉村昭彦：脳虚血後炎症．臨床神経科学 35(11):1327-1329 (2017)
  27. 七田　崇：脳梗塞と免疫．日本臨牀増刊号 75(5):1107-1113 (2017)
  28. 七田　崇、吉村昭彦：IL-23と炎症．臨床免疫・アレルギー科 67(1):16-22 (2017)
  29. 大星博明、七田　崇：DAMPsと炎症．日本臨牀 74(4):573-578 (2016)
  30. Shichita T, Yoshimura A. Inflammation in central nervous system diseases. Clin Exp Neurol. 7:18-27 (2016)
  31. 七田　崇、吉村昭彦：脳虚血と細胞死．実験医学増刊 34(7):105-109 (2016)
  32. 伊藤美菜子、七田　崇、森田林平、吉村昭彦：脳虚血と炎症．最新医学 71(2):243-249 (2016)
  33. 七田　崇、伊藤美菜子、吉村昭彦：脳虚血後炎症．脳循環代謝学会雑誌 26:135-139 (2015)
  34. 七田　崇、吉村昭彦：老化と脳虚血後炎症．別冊BIO Clinica 4(2):79-84 (2015)
  35. Shichita T, Ito M, Yoshimura A. Post-ischemic inflammation regulates neural damage and protection. Front Cell Neurosci. 8:319 (2014)
  36. 七田　崇、吉村昭彦、大星博明：脳梗塞と炎症．最新臨床脳卒中学（上）　日本臨牀72巻増刊号:111-115 (2014)
  37. 七田　崇、吉村昭彦、大星博明：脳虚血とTLR．分子脳血管病 12(4):396-400 (2013)
  38. Shichita T, Sakaguchi R, Ito M, Kondo T, Yoshimura A. Peroxiredoxin triggers cerebral post-ischemic inflammation. Inflammation and Regeneration. 33(3):150-155 (2013)
  39. 吉村昭彦、伊藤美菜子、近藤泰介、七田　崇：ペルオキシレドキシンによる脳虚血後炎症を惹起するメカニズム．生化学85(3):179-186 (2013)
  40. 七田　崇、吉村昭彦：脳虚血後炎症におけるDAMPsの役割．感染炎症免疫 43(1):66-70 (2013)
  41. 七田　崇、大星博明、北園孝成、吉村昭彦：脳虚血後炎症における自然免疫の役割．脳卒中 35:114-120 (2013)
  42. 七田　崇、吉村昭彦：脳虚血後炎症における自然免疫とT細胞の役割．炎症と免疫 21(2):117-122 (2013)
  43. 七田　崇、吉村昭彦：マクロファージによる脳梗塞後炎症の誘導．細胞工学 31(11):1225-1230 (2012)
  44. 七田　崇、吉村昭彦：ペルオキシレドキシンを介した虚血後の炎症と脳梗塞．血栓と循環 20(3):182-187 (2012)
  45. Shichita T, Ago T, Kamouchi M, Kitazono T, Yoshimura A, Ooboshi H. Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke. J Neurochem. 123 Suppl2:29-38 (2012)
  46. Shichita T, Sakaguchi R, Suzuki M, Yoshimura A. Post-ischemic inflammation in the brain. Front Immun. 3:132 (2012)
  47. 七田　崇、吉村昭彦：脳虚血疾患における免疫細胞の役割と新規治療戦略．細胞工学 30(10):1036-1041 (2011)
  48. 七田　崇、吉村昭彦：虚血性脳障害におけるIL-17産生性γδT細胞の役割．BIO Clinica 26(7):657-661 (2011)
  49. Shichita T, Muto G, Yoshimura A. T lymphocyte in the delayed phase of ischemic brain injury．Inflammation and Regeneration. 31(1):102-109 (2011)
  50. 七田　崇、吉村昭彦：虚血性疾患とサイトカイン．医学のあゆみ 234(5):551-556 (2010)
  51. 七田　崇、吉村昭彦：虚血性疾患とサイトカイン．実験医学別冊 28(12): 2011-2014 (2010)
  52. 七田　崇、吉村昭彦：脳虚血におけるIL-17産生性γδT細胞の役割．感染炎症免疫 40:69-72 (2010)
  53. 七田　崇、吉村昭彦：脳虚血におけるIL-17産生性γδT細胞の役割．Medical Science Digest 36:662-665 (2010)
  54. Ooboshi H, Ishikawa E, Kumai Y, Shichita T, Takada J, Ibayashi S. Potentials of gene therapy for neuroprotection and neurogenesis in brain ischemia. Recent Advances in Neurogenesis, Neuroregeneration and Neuroprotection, Suzuki S & Yonemitsu Y (eds), Resarch Signpost, Kerala, pp47-59 (2009)
  55. 七田　崇、岡田　靖：ずり応力依存性の血栓形成には２段階の血小板凝集過程が関与している．International Review of Thrombosis 2(3): 194-195 (2007)
  56. 七田　崇、緒方　利安、岡田　靖：脳梗塞急性期における頭頸部血管超音波診断のポイント．血栓と循環 15(2) (2007)
  57. 七田　崇、矢坂　正弘：奇異性脳塞栓症．脳と神経 58(11): 945-952 (2006)
  58. 七田　崇、緒方　利安、岡田　靖：rt-PA静注療法について．脳と循環 11:185-189 (2006)
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